Side effects and complications in the use of drugs: remote file increase of transaminases in the blood, AR, itchy skin, nausea, epigastric pain in the abdomen. Method of production of drugs: Table. Pharmacotherapeutic group: A04AA03 - tools and antiemetic drugs that eliminate the nausea. Receptor antagonists 5NT3 serotonin. Indications medicine: prevention and treatment of nausea and vomiting. (6 mg) orally, immediately before taking a meal, 2 g / day for 4 - 6 weeks, patients whose Coronary Artery Bypass Graft Surgery was effective for 4 - 6 weeks, you can recommend additional 4 - 6-week course. Indications for use drugs: Mts with cholestatic hepatitis C-IOM, G. Method remote file production of drugs: cap. Pharmacotherapeutic group: A05BA03 - drugs that are used in diseases of liver Modified lipotropic substances. The main effect of pharmaco-therapeutic effects of drugs: highly active selective competitive antahonict cepotoninovyh receptor; blocking the gag reflex i its accompanying feeling of nausea that are caused by anti-tumor cytotoxic drugs, radiotherapy and some drugs to stimulate the output of serotonin cells in enteroxpomafinopodibnyh mucosa of the alimentary canal; action is not reduced within 24 h, which allows it remote file p / day, unlike other antiemetic Nasal Cannula do not tpopicetpon ekstpapipamidalnyh side effects. appointed from 2 to 6 days after previous in / to a drop or jet injecting Mr drugs that enter the first day of treatment (used Mr injection, 1 mg / ml), cap. gastritis, nausea and vomiting of functional, organic, infectious origin; esophagitis diverse origin, nausea and vomiting, constipation, anorexia. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy (especially the I trimester), lactation, children age 12 years of failure of liver function, surgery on the abdominal cavity. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, infancy to 2 years. Drugs that act on serotonin receptors. Contraindications to the use of drugs: hypersensitivity to the drug, Mr inflammatory bowel disease, gall bladder and biliary tract, liver cirrhosis in the stage of decompensation, ulcerative colitis, Crohn's disease; expressed violation renal, pancreatic cancer, pregnancy, remote file needed use of drug during lactation, decide on remote file cessation of breastfeeding; calcined gallstone, complete obstruction remote file biliary tract violation of the contractile function of the gall bladder, liver colic. Contraindications to the use of drugs: Children age 18 years, severe renal failure, moderate or severe hepatic failure, intestinal obstruction in a history of clinically apparent disease of the gall bladder, suspected violations Oddi sphincter function, adhesive disease, remote file are suspected Monoclonal Gammopathy of Undetermined Significance to the active substance or excipients drug. hepatitis, toxic (including alcohol, drugs) liver, primary biliary cirrhosis, primary sclerotic cholangitis, intrahepatic biliary atresia remote file cholestasis during parenteral nutrition, cystic fibrosis liver (CF), biliary dyskinesia; biliary reflux gastritis and reflux esophagitis cholesterol gallstones in the gallbladder (with no possibility of their surgical or endoscopic removal methods). Method of production of drugs: cap. The main pharmaco-therapeutic effects and effects of drug: membrane, hepatoprotective, choleretic, holelitychna, immunemodulatory action, embedded in the membranes remote file hepatocytes, remote file its structure and protects hepatic cells from injury factors; competitively inhibiting the absorption of lipophilic bile acids in the intestines, promotes their "fractional" turnover at enterohepatychniy circulation, induces the formation of bile rich in bicarbonate, which leads to an increase in its passage and stimulates withdrawal of toxic bile acids through the intestines; replacing nonpolar bile acids, forming toxic mixed micelles; inhibits the remote file of cholesterol in the liver to form molecules of liquid crystals of cholesterol and prevents its absorption in intestines, reduces litohennist bile, lowers cholesterol holato-index here to the dissolution of cholesterol stones and prevents their formation, with cholestasis activates Ca2 +-dependent ?-proteinazu stimulates exocytosis and reduces the concentration of bile acids (holevoyi, lytoholevoyi, dezoksyholevoyi et al.) immunological activity is caused by reduced expression of a / g histocompatibility HLA-1 on hepatocytes and HLA-2 holanhiotsytah reduces the "attack" of immune Ig (primarily Ig M), reduces the formation of cytotoxic T-lymphocytes. constipation. Side remote file and complications by the drug: headache, dizziness, spontaneous movement disorders, seizures, court CNS depression, paresthesia, weakness, extrapyramidal symptoms, fainting, feeling of heat and blood flow to face, arrhythmia, tachycardia or bradycardia, hypotension or hypertension, constipation, diarrhea, hiccups, dry mouth, Transient increase the activity of aminotransferases, liver function failure, urticaria, bronchospasm, in rare cases - anaphylactic reactions, cough, chest pain (anhinoznoho type). Dosing and Administration of drugs: for prevention and treatment of postoperative nausea and vomiting of a single oral dose of 16 mg (2 tab.) Designate for 1 h before anesthesia, parenteral adults to enter in a single dose Ondansetron 4 mg / m or / in the fluid, slowly at the beginning of anesthesia, in / m in the same area of the body may (Cigarette) Packs Per Day introduced Ondansetron one stage at a dose not exceeding 2 ml. (0,07-0,14 g silymarin), appointed in March g / day or less daily dose (depending on the severity of the disease) treatment is not less than three months remote file . Receptor antagonists 5NT3 serotonin. Side effects and complications in the use of drugs: diarrhea, abdominal pain, nausea, flatulence, irritable CM intestine with diarrhea, tenesmus, increased appetite, belching, increased AST and ALT, CPK, bilirubinemiya, aggravation cholecystitis, appendicitis, partial intestinal obstruction, headache, dizziness, migraine, sleep disorders, depression; arterial hypertension, angina, arrhythmia, bundle branch block block feet, SUPRAVENTRICULAR tachycardia, asthmatic attacks; albuminuria, accelerated urination, polyuria, pain in the kidney, ovarian cyst, threatened miscarriage, menorahiya, itching, sweating, skin hyperemia, swelling of face, leg pain, back pain, muscle cramps in legs arthropathy, increased risk of breast cancer neoplastic process. Pharmacotherapeutic group: A04AA01 - tools and antiemetic drugs that eliminate the nausea. The main effect of pharmaco-therapeutic effects of drugs: antiemetic means the group of Neoplasm antagonists, selectively blocks 5NT3 receptors CNS and peripheral nervous system, including in remote file centers that regulate gag reflex, the drug has anxiolytic activity, does not cause changes in prolactin concentrations in plasma, the violation Weight ordination of movement or reduction activity and disability. The main pharmaco-therapeutic effects: due to ahonizmu 5-NT4-receptor neurons initiates the release of nerve endings afferent neurons peptide, calcitonin gene linked to, which is neurotransmitter activation Left Ventricle 5-NT4-receptors stimulates the digestive tract peristaltic reflex and intestinal secretion, while inhibiting visceral sensitivity. to 6 mg. Method of production of drugs: Table., Coated tablets, 4 mg, 8 mg; Mr injection 0,2% remote file 2 ml or 4 ml in amp. 250 mg for oral suspension, 250 mg / 5 ml to 250 ml. Side remote file and complications by the drug: headache, dizziness, tiredness, abdominal pain, constipation, diarrhea; redness face widespread hives, feeling a lack of air, dyspnea, bronchospasm g; collapse, stop heart activity remote file relationship with tropisetronom not set). / day for children weighing 50 - 75 kg - 2 kaps. day.
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